括约肌内注射肉毒杆菌毒素对食管贲门失弛缓症的长期治疗有效。

Intrasphincteric injection of botulinum toxin is effective in long-term treatment of esophageal achalasia.

作者信息

Annese V, Basciani M, Borrelli O, Leandro G, Simone P, Andriulli A

机构信息

Division of Gastroenterology, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy.

出版信息

Muscle Nerve. 1998 Nov;21(11):1540-2. doi: 10.1002/(sici)1097-4598(199811)21:11<1540::aid-mus27>3.0.co;2-2.

DOI:10.1002/(sici)1097-4598(199811)21:11<1540::aid-mus27>3.0.co;2-2

PMID:9771683

Abstract

We investigated the long-term efficacy and safety of intrasphincteric injections of botulinum toxin (100 U) in 57 patients with esophageal achalasia. One month after treatment, 50 patients had improved (88%); both symptom score and LES pressure were significantly reduced (P < 0.001). After a mean follow-up of 24+/-15 months (range 6-48), 43 patients (75%) are still in remission, although repeat injections of toxin were needed to achieve a stable effect on symptoms.

摘要

我们研究了57例食管贲门失弛缓症患者行括约肌内注射肉毒杆菌毒素（100单位）的长期疗效和安全性。治疗1个月后，50例患者病情改善（88%）；症状评分和食管下括约肌压力均显著降低（P<0.001）。平均随访24±15个月（范围6 - 48个月）后，43例患者（75%）仍处于缓解状态，尽管需要重复注射毒素以维持对症状的稳定疗效。