残余偶极耦合作为全氘代寡糖中新的构象限制因素
Residual dipolar couplings as new conformational restraints in isotropically 13C-enriched oligosaccharides.
作者信息
Kiddle G R, Homans S W
机构信息
Centre for Biomolecular Sciences, University of St. Andrews, FIFE, UK.
出版信息
FEBS Lett. 1998 Sep 25;436(1):128-30. doi: 10.1016/s0014-5793(98)01112-0.
PMID:9771907
Abstract
We report the measurement of residual dipolar couplings for l3C-enriched NeuNAcalpha2-3Galbeta1-4Glc in a dilute liquid-crystalline medium. These couplings provide long-range conformational restraints that hitherto have not been available for oligosaccharides. We utilise these restraints in dynamical simulated annealing calculations, which support current models of the solution behaviour of the trisaccharide.
摘要
我们报告了在稀液晶介质中对富含¹³C的NeuNAcα2-3Galβ1-4Glc的剩余偶极耦合的测量。这些耦合提供了长程构象限制，而这是迄今为止寡糖所没有的。我们在动态模拟退火计算中利用这些限制，这支持了当前三糖溶液行为的模型。
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