边缘叶脑炎和抗利尿激素分泌异常综合征揭示小细胞间变性肺癌：MRI及免疫学表现
[Limbic encephalitis and SIADH revealing small-cell anaplastic lung cancer: MRI and immunologic findings].
作者信息
Touzé E, Auliac J B, Carras P, Lecannelie G, Genero-Gygax M, Flocard F
机构信息
Service de Neurologie, Hôpital d'Instruction des Armées Legouest, Metz.
出版信息
Rev Neurol (Paris). 1998 Jul;154(6-7):539-41.
Paraneoplastic limbic encephalitis (PLE) is a manifestation of clinico pathological entity encephalo-myelo-neuropathy associated with anti-neuronal antibodies type 1 (ANNA-1 also called anti-Hu). Isolated PLE is rare. We reported a case of PLE in a 61-year-old heavy smoker man. An inappropriate antidiuretic hormone secretion syndrome was associated. Cranial MRI showed hyperintensity in amygdalo-hippocampic regions on T2 weighted sequences which appeared hypointense on T1-weighted sequences without gadolinium enhancement. Anti-Hu antibodies were absent in serum and in CSF. Despite chemotherapy, he died 18 months after disease onset. Our patient presented PLE without myelonouropathy and without ANNA-1 which suggests a different immunopathology.
副肿瘤性边缘叶脑炎（PLE）是一种临床病理实体性脑脊髓神经病的表现，与1型抗神经元抗体（ANNA - 1，也称为抗Hu）相关。孤立性PLE较为罕见。我们报告了一例61岁重度吸烟男性的PLE病例。该病例伴有抗利尿激素分泌异常综合征。头颅MRI显示在T2加权序列上杏仁核 - 海马区呈高信号，在T1加权序列上无钆增强时呈低信号。血清和脑脊液中均未检测到抗Hu抗体。尽管进行了化疗，但患者在疾病发作18个月后死亡。我们的患者表现为无脊髓神经病且无ANNA - 1的PLE，这提示了一种不同的免疫病理学。
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