J Periodontol. 1998 Sep;69(9):1081-4. doi: 10.1902/jop.1998.69.9.1081.
These Guidelines apply to products used to promote the regeneration of periodontal tissues lost due to periodontal diseases or other causes. Periodontal regeneration is defined histologically as regeneration of the tooth's supporting tissues, including alveolar bone, periodontal ligament, and cementum over a previously diseased root surface. Regenerative procedures must enhance the formation of a new attachment apparatus demonstrated by randomized controlled histological studies in animals, verified by human histologic evidence, and supported by beneficial results in human randomized controlled clinical trials.
本指南适用于用于促进因牙周疾病或其他原因而丧失的牙周组织再生的产品。牙周再生在组织学上定义为牙齿支持组织的再生，包括在先前患病的牙根表面上的牙槽骨、牙周韧带和牙骨质。再生程序必须通过动物随机对照组织学研究证明能增强新附着装置的形成，并得到人类组织学证据的验证以及人类随机对照临床试验的有益结果的支持。
