Ivanov V P, Churnosov M I, Kirilenko A I
Department of Medical Biology, Genetics, and Ecology, Kursk State Medical University, Russia.
Genetika. 1998 Aug;34(8):1163-7.
A significant effect of the population structure on the incidence of multifactorial diseases affecting the viability of the adult population was found in rural districts of Kursk oblast. The diseases studied were chronic bronchitis, pulmonary emphysema, pneumosclerosis, and atherosclerosis. The incidence of multifactorial pathology increased with an increase in the homozygosity level of district populations. On average, the population structure affected the incidence of multifactorial diseases by 30-50%.
在库尔斯克州的农村地区发现,人口结构对影响成年人口生存能力的多因素疾病发病率有显著影响。所研究的疾病包括慢性支气管炎、肺气肿、肺硬化和动脉粥样硬化。多因素病理学的发病率随着地区人群纯合性水平的增加而上升。平均而言,人口结构对多因素疾病发病率的影响为30%至50%。