Sherman A L, Willick S P, Cardenas D D
Department of Rehabilitation Medicine, University of Washington, Seattle 98105, USA.
Arch Phys Med Rehabil. 1998 Oct;79(10):1303-5. doi: 10.1016/s0003-9993(98)90280-5.
Recently botulinum toxin has been used with increasing frequency as a safe and effective treatment for many previously refractory conditions associated with excessive muscle activity. The indications for use of botulinum toxin injection continue to expand. This report describes the case of an 83-year-old woman with a history of diabetes mellitus and lumbar spinal stenosis who developed a severe focal dystonia of the left great toe, such that the toe maintained the extended position. Functionally, the resultant deformity prevented the patient from wearing shoes. In addition, the patient had significant pain in the left great toe. Under needle electromyographic localization, 50 units of botulinum toxin were injected into the left extensor hallucis longus muscle. Two weeks after the injection the patient was symptom free and could place her left foot into a shoe. Seven months later, she remained symptom free. This case illustrates that localized injection of botulinum toxin to a specific lower limb muscle can effectively result in decreased muscle activity and functional improvement.
近年来,肉毒杆菌毒素作为一种安全有效的治疗方法,越来越频繁地用于许多以前难以治疗的与肌肉活动过度相关的病症。肉毒杆菌毒素注射的适应症不断扩大。本报告描述了一名83岁女性的病例,她有糖尿病和腰椎管狭窄病史,出现了左拇趾严重的局灶性肌张力障碍,导致拇趾保持伸展位。在功能上,由此产生的畸形使患者无法穿鞋。此外,患者左拇趾有明显疼痛。在针电极肌电图定位下,将50单位肉毒杆菌毒素注射到左拇长伸肌中。注射两周后,患者症状消失,能够将左脚放入鞋中。七个月后,她仍然没有症状。该病例表明,向特定下肢肌肉局部注射肉毒杆菌毒素可有效降低肌肉活动并改善功能。