Santos J, Herranz M, Pérez de Castro I, Pellicer A, Fernández-Piqueras J
Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Spain.
Oncogene. 1998 Aug 20;17(7):925-9. doi: 10.1038/sj.onc.1202009.
In a previous work we provided preliminary evidence of the existence of a putative tumor suppressor gene region on the distal part of chromosome 4 in gamma-radiation-induced T-cell lymphomas of (C57BL/6J x RF/J) F1 hybrid mice. This region, named as TLSR2 (Thymic Lymphoma Suppressor Region 2), was located centered at D4Mit54. A more detailed allelotype analysis in the mentioned tumors with new informative microsatellites on distal chromosome 4 region, as well as in thymic lymphomas induced with gamma-rays in F1 hybrids generated from reciprocal crosses between the strains C57BL/6J and BALB/cJ, and having in mind the new map position of D4Mit205b, allowed us to confirm the existence of TLSR2 and to define it more precisely as centered at D4Mit205b. In addition, we identified a new candidate region, named as TLSR3 (Thymic Lymphoma Suppressor Region 3), located between the Mom-1 locus and D4Mit68, as the site of another putative tumor suppressor region involved in thymic lymphomagenesis.
在之前的一项研究中，我们提供了初步证据，证明在（C57BL/6J×RF/J）F1杂交小鼠的γ射线诱导的T细胞淋巴瘤中，4号染色体远端存在一个假定的肿瘤抑制基因区域。这个区域被命名为TLSR2（胸腺淋巴瘤抑制区域2），位于以D4Mit54为中心的位置。对上述肿瘤进行更详细的等位基因分析，使用4号染色体远端区域上新的信息丰富的微卫星，以及在由C57BL/6J和BALB/cJ品系之间的正反交产生的F1杂种中γ射线诱导的胸腺淋巴瘤中进行分析，并考虑到D4Mit205b的新图谱位置，使我们能够确认TLSR2的存在，并将其更精确地定义为以D4Mit205b为中心。此外，我们确定了一个新的候选区域，命名为TLSR3（胸腺淋巴瘤抑制区域3），位于Mom-1位点和D4Mit68之间，作为另一个参与胸腺淋巴瘤发生的假定肿瘤抑制区域的位点。
