Nakajima S, Bamba T
Department of Medicine/Gastroenterology, Social Insurance Shiga Hospital.
Nihon Rinsho. 1998 Sep;56(9):2291-6.
Progress in drug therapy, endoscopic hemostasis and interventional radiology reduced the number of surgical operation for gastrointestinal bleeding. In the upper gastrointestinal bleeding, histamine H2-blockers reduced the number of operation. Proton pump inhibitors (PPI) were as effective as H2-blockers, or more effective than H2-blockers. Intragastric pH was raised to over 6 and was maintained in high level with the therapies using intravenous PPI injection. Oral administration of PPI also raised gastric pH to over 6 on the next day of the treatment, and then succeeded to treat bleeding. More effective and reliable therapies using PPIs are needed for rapid raising of intragastric pH and maintaining it in high level to treat upper gastrointestinal bleeding.
药物治疗、内镜止血和介入放射学的进展减少了胃肠道出血的外科手术数量。在上消化道出血方面，组胺H2受体阻滞剂减少了手术数量。质子泵抑制剂（PPI）与H2受体阻滞剂效果相当，或比H2受体阻滞剂更有效。通过静脉注射PPI进行治疗，胃内pH值可升至6以上并维持在高水平。治疗第二天口服PPI也可使胃内pH值升至6以上，进而成功治疗出血。需要更有效、可靠的PPI治疗方法来快速提高胃内pH值并维持在高水平，以治疗上消化道出血。
