Calafell F, Shuster A, Speed W C, Kidd J R, Kidd K K
Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-8005, USA.
Eur J Hum Genet. 1998 Jan;6(1):38-49. doi: 10.1038/sj.ejhg.5200151.
Forty-five dinucleotide short tandem repeat polymorphisms were typed in ten large samples of a globally distributed set of populations. Although these markers had been selected for high heterozygosity in European populations, we found them to be sufficiently informative for linkage analysis in non-Europeans. Heterozygosity, mean number of alleles, and mean number of private alleles followed a common trend: they were highest in the African samples, were somewhat lower in Europeans and East Asians, and were lowest in Amerindians. Genetic distances also reflected this pattern, and distances modelled after the stepwise mutation model yielded trees that were less in agreement with other genetic and archaeological evidence than distances based on differentiation by drift (FST). Genetic variation in non-Africans seems to be a subset of that in Africans, supporting the replacement hypothesis for the origin of modern humans.
在一组全球分布的人群的十个大样本中，对45个二核苷酸短串联重复多态性进行了分型。尽管这些标记是为在欧洲人群中具有高杂合性而选择的，但我们发现它们对非欧洲人群的连锁分析也具有足够的信息量。杂合性、等位基因平均数和私有等位基因平均数呈现出共同趋势：在非洲样本中最高，在欧洲人和东亚人中略低，在美洲印第安人中最低。遗传距离也反映了这种模式，基于逐步突变模型建模的距离所产生的树状图与其他遗传和考古证据的一致性不如基于遗传漂变分化（FST）的距离。非洲以外人群的遗传变异似乎是非洲人群遗传变异的一个子集，这支持了现代人类起源的替代假说。
