Carde P, Cosset J M
Institut Gustave-Roussy (Service de médecine C. Suzanne Axel), Villejuif.
Rev Prat. 1998 May 15;48(10):1075-81.
Cure is warranted in most cases of localized Hodgkin's disease, the more frequent ones. However, after 10 years of follow-up, early and late mortality of iatrogenic origin exceed casualties related to tumor progression. Reductions in irradiation doses and fields, as well as wiser chemotherapy choices attempt to circumvent these complications. Nevertheless, as long as the mechanism of disease propagation and the prognostic factors are not better defined, only pragmatic approaches are being tested. Large cooperative trials are therefore needed to improve the outcome.
在大多数局限性霍奇金淋巴瘤(较为常见的类型)病例中,治愈是有保障的。然而,经过10年的随访,医源性原因导致的早期和晚期死亡率超过了与肿瘤进展相关的死亡人数。减少照射剂量和照射野,以及更明智地选择化疗方案,试图规避这些并发症。尽管如此,只要疾病传播机制和预后因素尚未得到更明确的界定,就只能尝试一些务实的方法。因此,需要进行大规模的合作试验来改善治疗结果。