人类专性胞内病原体沙眼衣原体的基因组序列。

Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis.

作者信息

Stephens R S, Kalman S, Lammel C, Fan J, Marathe R, Aravind L, Mitchell W, Olinger L, Tatusov R L, Zhao Q, Koonin E V, Davis R W

机构信息

Program in Infectious Diseases, University of California, Berkeley, CA 94720, USA.

出版信息

Science. 1998 Oct 23;282(5389):754-9. doi: 10.1126/science.282.5389.754.

DOI:10.1126/science.282.5389.754

PMID:9784136

Abstract

Analysis of the 1,042,519-base pair Chlamydia trachomatis genome revealed unexpected features related to the complex biology of chlamydiae. Although chlamydiae lack many biosynthetic capabilities, they retain functions for performing key steps and interconversions of metabolites obtained from their mammalian host cells. Numerous potential virulence-associated proteins also were characterized. Several eukaryotic chromatin-associated domain proteins were identified, suggesting a eukaryotic-like mechanism for chlamydial nucleoid condensation and decondensation. The phylogenetic mosaic of chlamydial genes, including a large number of genes with phylogenetic origins from eukaryotes, implies a complex evolution for adaptation to obligate intracellular parasitism.

摘要

对1042519碱基对的沙眼衣原体基因组进行分析后，发现了与衣原体复杂生物学相关的意外特征。尽管衣原体缺乏许多生物合成能力，但它们仍保留了执行从其哺乳动物宿主细胞获得的代谢物的关键步骤和相互转化的功能。还鉴定了许多潜在的毒力相关蛋白。识别出了几种真核染色质相关结构域蛋白，这表明衣原体类核凝聚和解凝聚存在类似真核生物的机制。衣原体基因的系统发育镶嵌现象，包括大量起源于真核生物的系统发育基因，意味着其为适应专性细胞内寄生而经历了复杂的进化。