Choudhury S R, Ueshima H, Okayama A, Kita Y, Miyoshi Y
Department of Health Science, Shiga University of Medical Science, Otsu, Japan.
Hypertens Res. 1998 Sep;21(3):175-8. doi: 10.1291/hypres.21.175.
An association has been found between high blood pressure (BP) and the regular consumption of alcohol in epidemiological studies, and a repeated withdrawal reaction to alcohol is considered one of the mechanisms of high BP in drinkers. In this study, we investigated the association between BP and alcohol consumption on the previous day in regular male drinkers. The study participants were 551 men aged 20 to 59 yr who drank alcohol regularly. BP was measured and information on daily alcohol intake was obtained from each participant by a questionnaire, which also asked whether alcohol had been consumed on the day before BP measurement. Age-adjusted BP was compared between participants who had (n=504, 91.6%) and those who had not (n=47, 8.4%) consumed alcohol on the previous day. There were no significant differences between the two groups with regard to BP or body mass index. Even after excluding subjects who were receiving anti-hypertensive drugs, there was still no significant difference in age-adjusted BP between the two groups. Our study found no association between BP and alcohol consumption on the previous day in regular male drinkers, which implies that alcohol withdrawal after 1 d of abstinence cannot explain the high blood pressure found in regular drinkers in this Japanese middle-aged population.
在流行病学研究中,已发现高血压(BP)与经常饮酒之间存在关联,并且对酒精的反复戒断反应被认为是饮酒者高血压的发病机制之一。在本研究中,我们调查了规律饮酒的男性中BP与前一天酒精摄入量之间的关联。研究参与者为551名年龄在20至59岁之间且经常饮酒的男性。测量了BP,并通过问卷调查从每位参与者处获取每日酒精摄入量信息,问卷还询问了在测量BP的前一天是否饮酒。比较了前一天饮酒的参与者(n = 504,91.6%)和未饮酒的参与者(n = 47,8.4%)之间的年龄调整BP。两组在BP或体重指数方面无显著差异。即使排除正在接受抗高血压药物治疗的受试者后,两组之间的年龄调整BP仍无显著差异。我们的研究发现,规律饮酒的男性中BP与前一天酒精摄入量之间无关联,这意味着戒酒1天后的酒精戒断不能解释该日本中年人群中规律饮酒者出现的高血压现象。