通过Ras的信号转导。

Signal transduction via Ras.

作者信息

Wittinghofer A

机构信息

Max-Planck-Institut für molekulare Physiologie, Dortmund, Germany.

出版信息

Biol Chem. 1998 Aug-Sep;379(8-9):933-7.

PMID:9792425

Abstract

Ras is a major regulator of cell growth. It is a GTP-binding protein that functions as a molecular switch, cycling between the GDP-bound OFF and GTP-bound ON states. In the GTP-bound state it interacts with effector proteins that mediate the biological function. It is found as an oncogene in about 30% of human tumors. Structural and mechanistic studies on Ras and its interaction with effectors and GAP will be discussed in the context of the biology and pathophysiology of this protein.

摘要

Ras是细胞生长的主要调节因子。它是一种GTP结合蛋白，起分子开关的作用，在结合GDP的关闭状态和结合GTP的开启状态之间循环。在结合GTP的状态下，它与介导生物学功能的效应蛋白相互作用。在约30%的人类肿瘤中，它被发现是一种癌基因。将在该蛋白的生物学和病理生理学背景下讨论关于Ras及其与效应蛋白和GAP相互作用的结构和机制研究。