Bertel O, Straumann E, Balmelli N, Nägeli B
Medizinische Klinik, Stadtspital Triemli, Zürich.
Schweiz Med Wochenschr. 1998 Sep 26;128(39):1428-35.
Cardiogenic shock (CS), defined as forward failure combined with systolic blood pressure < 90 mm Hg and reduced organ perfusion despite adequate volume loading, still has a grim prognosis with mortality rates of 80-100% if the causes are left untreated. The most frequent conditions underlying CS are acute myocardial infarction, acute and severe aortic or mitral incompetence, rapidly progressive dilatative cardiomyopathy and hypertrophic obstructive cardiomyopathy. Whereas correct conservative management by drugs and pacing may be life saving in the latter, the other conditions require early invasive management. Indications for cardiac surgery and circulatory assistance are given for mechanical complications leading to CS. In CS complicating myocardial infarction, comprehensive management with early invasive revascularization and intraaortic balloon pumping may result in improved survival compared with the disappointing outcome of medical treatment, including fibrinolysis. This strategy can be offered to the majority of infarct patients in CS, who are primarily admitted to hospitals not equipped for interventional cardiology or cardiac surgery. Between-hospital transfer of these patients for PTCA (or surgery) and advanced intensive care has been shown to be feasible and safe.
心源性休克(CS)定义为尽管充分扩容但仍存在前向性衰竭并伴有收缩压<90 mmHg以及器官灌注减少,若病因未得到治疗,其预后仍然严峻,死亡率达80 - 100%。导致CS的最常见病因是急性心肌梗死、急性重度主动脉瓣或二尖瓣关闭不全、快速进展性扩张型心肌病和肥厚性梗阻性心肌病。虽然药物和起搏的正确保守治疗对后者可能挽救生命,但其他情况需要早期侵入性治疗。心脏手术和循环辅助的适应证适用于导致CS的机械性并发症。在并发心肌梗死的CS中,与包括溶栓在内的药物治疗令人失望的结果相比,早期侵入性血运重建和主动脉内球囊反搏的综合治疗可能提高生存率。这种策略可应用于大多数CS的梗死患者,这些患者最初入住的医院不具备介入心脏病学或心脏手术条件。已证明将这些患者转院进行经皮冠状动脉腔内血管成形术(PTCA)(或手术)和高级重症监护是可行且安全的。