Hessol N A, Fuentes-Afflick E, Bacchetti P
Department of Medicine, Medical Effectiveness Research Center for Diverse Populations, Epidemiology and Biostatistics, University of California San Francisco, 94122, USA.
Obstet Gynecol. 1998 Nov;92(5):814-22. doi: 10.1016/s0029-7844(98)00310-x.
To determine whether racial differences in risk of low birth weight infants among black and white parents can be attributed to differences in demographic, behavioral, medical, and socioeconomic factors.
We analyzed 203,815 singleton births from the 1992 California birth certificate data set for the risk of very low birth weight (500-1499 g) and moderately low birth weight (1500-2499 g) infants. Additional study variables included maternal (race, age, education, marital status, parity, obstetric history, tobacco use, medical complications, medical insurance, and use of prenatal care), paternal (race, age, and education), infant (gestational age and gender), and community (median household income from the 1990 US Census) characteristics.
For both very low and moderately low birth weight infants, the unadjusted risk associated with parental race showed a gradient of risk, from highest to lowest, for black mother/black father, black mother/white father, white mother/black father, and white mother/white father parents. After adjusting for other risk factors, the odds ratio associated with black mother/black father parents was reduced from 3.37 to 1.73 for very low birth weight infants and from 2.51 to 1.60 for moderately low birth weight infants, but both remained elevated. Interracial parents no longer had an elevated risk of very low birth weight infants and white mother/black father parents no longer had an elevated risk of moderately low birth weight, compared with white parents.
After controlling for parental, infant, and community factors, most but not all of the increased risk of low birth weight infants associated with black parental race was explained.
确定黑人和白人父母所生低体重儿风险的种族差异是否可归因于人口统计学、行为、医学和社会经济因素的差异。
我们分析了1992年加利福尼亚出生证明数据集的203,815例单胎分娩,以研究极低出生体重(500 - 1499克)和中度低出生体重(1500 - 2499克)婴儿的风险。其他研究变量包括母亲(种族、年龄、教育程度、婚姻状况、产次、产科病史、吸烟情况、医学并发症、医疗保险和产前护理的使用情况)、父亲(种族、年龄和教育程度)、婴儿(胎龄和性别)以及社区(1990年美国人口普查的家庭收入中位数)特征。
对于极低出生体重和中度低出生体重婴儿,未经调整的与父母种族相关的风险呈现出一个风险梯度,从最高到最低依次为黑人母亲/黑人父亲、黑人母亲/白人父亲、白人母亲/黑人父亲和白人母亲/白人父亲的父母。在调整其他风险因素后,与黑人母亲/黑人父亲的父母相比,极低出生体重婴儿的优势比从3.37降至1.73,中度低出生体重婴儿的优势比从2.51降至1.60,但两者仍处于较高水平。与白人父母相比,异族通婚的父母所生极低出生体重婴儿的风险不再升高,白人母亲/黑人父亲的父母所生中度低出生体重婴儿的风险也不再升高。
在控制了父母、婴儿和社区因素后,与黑人父母种族相关的低出生体重婴儿增加的风险大部分但并非全部得到了解释。