Hemminki K, Vaittinen P
Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden.
Cancer Epidemiol Biomarkers Prev. 1998 Oct;7(10):865-8.
The Swedish Family-Cancer Database was used to analyze relationships between parents and offspring with in situ cancers and between in situ cancers in one generation and invasive cancer in the other generation. A total of 130,000 in situ cancers and close to 400,000 invasive cancers were included from 1959 to 1994. The data on family relationships and cancers came from registered sources and should be free from bias. The offsprings' familial relative risks (FRRs) were calculated for concordant and discordant parental cancer sites. The most common male in situ site was skin (both melanoma and precancerous epithelial lesion), whereas cervix, breast, and skin were common female sites. Increased FRRs were observed for concordant sites: colon, breast, cervix, skin (melanoma), and, in males, precancerous epithelial lesions. The findings were consistent when in situ cancer-in situ cancer and in situ cancer-invasive cancer relationships were explored. FRRs were higher for in situ colon cancer and melanoma than the respective estimates in invasive cancers, and for the remaining sites, they were equal or somewhat lower. At discordant sites, increased FRRs of in situ cancers were observed for female breast and melanoma and, at many sites, implicated in tobacco and human papilloma virus carcinogenesis, together with cervix. Family histories of in situ cancers deserve clinical attention.
瑞典家庭癌症数据库用于分析原位癌患者父母与子女之间的关系，以及一代中的原位癌与另一代中的浸润性癌之间的关系。1959年至1994年期间共纳入了130,000例原位癌和近400,000例浸润性癌。家庭关系和癌症数据来自登记来源，应无偏差。计算了后代在父母癌症部位一致和不一致情况下的家族相对风险（FRR）。男性最常见的原位癌部位是皮肤（黑色素瘤和癌前上皮病变），而女性常见的部位是子宫颈、乳腺和皮肤。在一致的部位观察到FRR增加：结肠、乳腺、子宫颈、皮肤（黑色素瘤），对于男性来说，还有癌前上皮病变。在探索原位癌-原位癌和原位癌-浸润性癌关系时，结果是一致的。原位结肠癌和黑色素瘤的FRR高于浸润性癌的相应估计值，对于其余部位，它们相等或略低。在不一致的部位，观察到女性乳腺癌和黑色素瘤原位癌的FRR增加，并且在许多部位，与烟草和人乳头瘤病毒致癌作用有关，还有子宫颈。原位癌的家族史值得临床关注。
