Magga J, Vuolteenaho O, Tokola H, Marttila M, Ruskoaho H
Department of Pharmacology and Toxicology, University of Oulu, Finland.
Ann Med. 1998 Aug;30 Suppl 1:39-45.
Atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP) and C-type natriuretic peptide are the known members of the mammalian natriuretic peptide system. ANP and BNP genes are expressed in a specific manner in cardiac myocytes. They are natriuretic and diuretic hormones and cause vasorelaxation. ANP is mainly synthesized in the atria of the normal adult heart. However, ventricular hypertrophy is characterized by an augmentation of the synthesis and release of ANP from the ventricles. BNP is expressed in both the atria and the ventricles, but is mainly released from the ventricles. The major determinant of ANP and BNP secretion is wall stretch, and the levels of BNP messenger RNA increase substantially in response to cardiac overload. Acute increase in BNP gene expression occurs within 1 h and mimics the rapid induction of proto-oncogenes in response to haemodynamic stress. BNP can be used as a myocyte-specific marker to identify mechanisms that couple acute mechanical overload to alterations in cardiac gene expression.
心房利钠肽（ANP）、B型利钠肽（BNP）和C型利钠肽是哺乳动物利钠肽系统中已知的成员。ANP和BNP基因在心肌细胞中以特定方式表达。它们是利钠和利尿激素，可引起血管舒张。ANP主要在正常成年心脏的心房中合成。然而，心室肥厚的特征是心室中ANP的合成和释放增加。BNP在心房和心室中均有表达，但主要从心室释放。ANP和BNP分泌的主要决定因素是壁张力，并且BNP信使核糖核酸的水平会因心脏负荷过重而大幅增加。BNP基因表达的急性增加在1小时内发生，类似于原癌基因在血流动力学应激反应中的快速诱导。BNP可用作心肌细胞特异性标志物，以识别将急性机械负荷与心脏基因表达改变联系起来的机制。
