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[经皮内镜下胃造口术(PEG)在妇科肿瘤上消化道梗阻中的应用]

[Percutaneous endoscopic gastrostomy (PEG) in upper gastrointestinal tract occlusion in gynecologic oncology].

作者信息

Campagnutta E, Cannizzaro R, De Cicco M, De Piero G, Giorda G, Sopracordevole F, Parin A, Scarabelli C

机构信息

Divisione di Oncologia Chirurgica Ginecologica, Centro di Riferimento Oncologico (CRO), Aviano, Pordenone.

出版信息

Minerva Ginecol. 1998 Jul-Aug;50(7-8):305-11.

PMID:9808954
Abstract

BACKGROUND AND AIMS

Intestinal obstruction is a frequent cause of death in patients suffering from gynecological cancer, who have undergone multiple treatment in the form of surgery and/or chemotherapy and/or radiotherapy. The usual form of rescue treatment consists in the use of a nasogastric tube to administer support and analgesic treatment. Surgical gastrostomy is not a viable proposition in these extremely weak patients with large masses compressing and displacing the stomach. Percutaneous endoscopic gastrostomy (PEG), a technique first introduced for nutritional purposes, can be beneficially used to achieve decompression in these patients.

METHODS

PEG was performed in a total of 67 patients who had already undergone multiple treatment for abdominal-pelvic neoplasia with upper gastrointestinal obstruction, who could no longer be operated and who had a life expectancy of less than sixty days. In three cases positioning was not possible owing to the lack of transillumination of the gastric and abdominal wall. 54/64 patients had previously undergone at least two operations.

RESULTS

Esophagogastric lesions were found in 29% of patients, some of which were attributed to the nasogastric tube. Symptomatic wellbeing was obtained in 76.5% a few days after PEG. PEG remained in situ from 4 to 472 days. Slight peristomal infection was observed in 9% of cases. In seven cases it was necessary to add octreotide owing to the reappearance of symptoms.

CONCLUSIONS

PEG is relatively easy to use and allows obstructive symptoms to be resolved in the majority of patients. Special medical skills are not required and the patient may be easily managed at home together with support therapy and pain management. Once PEG has been performed, it is possible to take fluids and semi-liquid foods, offering the patient a chance to taste flavours which have often been forgotten. PEG enables neoadjuvant chemotherapy to be performed in patients with previously untreated intestinal obstruction.

摘要

背景与目的

肠梗阻是妇科癌症患者死亡的常见原因,这些患者已经接受了手术和/或化疗和/或放疗等多种治疗。通常的抢救治疗方式是使用鼻胃管进行支持和镇痛治疗。对于这些因巨大肿块压迫和移位胃部而极度虚弱的患者,手术胃造口术并非可行方案。经皮内镜胃造口术(PEG)最初是为营养目的而引入的一种技术,可有效用于这些患者的减压。

方法

对67例因上消化道梗阻而接受过腹部 - 盆腔肿瘤多次治疗、无法再进行手术且预期寿命不足60天的患者实施了PEG。有3例因胃和腹壁缺乏透光性而无法定位。64例患者中有54例此前至少接受过两次手术。

结果

29%的患者发现食管胃病变,其中一些归因于鼻胃管。PEG术后几天,76.5%的患者症状得到缓解。PEG留置时间为4至472天。9%的病例观察到轻微的造口周围感染。7例患者因症状复发需要加用奥曲肽。

结论

PEG使用相对简便,可使大多数患者的梗阻症状得到缓解。不需要特殊的医疗技能,患者在家中结合支持治疗和疼痛管理可轻松得到处理。一旦实施PEG,患者可以摄入液体和半流质食物,让患者有机会品尝常常被遗忘的味道。PEG使先前未经治疗的肠梗阻患者能够进行新辅助化疗。

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