哺乳动物多梳蛋白家族基因被归类为一类由B细胞受体交联诱导的新型早期反应基因。

Mammalian Polycomb group genes are categorized as a new type of early response gene induced by B-cell receptor cross-linking.

作者信息

Hasegawa M, Tetsu O, Kanno R, Inoue H, Ishihara H, Kamiyasu M, Taniguchi M, Kanno M

机构信息

Center for BioMedical Science, School of Medicine, Chiba University and CREST of the Japan Science and Technology Corporation.

出版信息

Mol Immunol. 1998 Jun;35(9):559-63. doi: 10.1016/s0161-5890(98)00048-0.

DOI:10.1016/s0161-5890(98)00048-0

PMID:9809583

Abstract

Polycomb group (PcG) genes were initially described in Drosophila melanogaster as regulators of the homeobox gene. Four mammalian homologues, mel-18, bmi-1, M33 and rae-28, are analyzed in this study. They not only regulate mammalian homeotic genes by analogy with their Drosophila counterparts, but also have some influence on the growth and differentiation of B lymphocytes. Here we report that these four mammalian PcG genes are rapidly induced after antigen-receptor cross-linking in B cells. Thus we would like to propose that mammalian PcG genes can be categorized as a new type of immediate early gene.

摘要

多梳蛋白家族（PcG）基因最初在黑腹果蝇中被描述为同源异型盒基因的调节因子。本研究分析了四种哺乳动物同源物，即mel-18、bmi-1、M33和rae-28。它们不仅通过与其果蝇对应物类比来调节哺乳动物的同源异型基因，而且对B淋巴细胞的生长和分化也有一定影响。在此我们报告，这四种哺乳动物PcG基因在B细胞中抗原受体交联后会迅速被诱导。因此我们提议将哺乳动物PcG基因归类为一种新型的立即早期基因。