Mazzio E A, Harris N, Soliman K F
College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, USA.
Planta Med. 1998 Oct;64(7):603-6. doi: 10.1055/s-2006-957530.
Glial cell monoamine oxidase (MAO) activity has been implicated as a contributor to oxidative neuronal damage associated with various neurodegenerative diseases. The attenuation of MAO activity may provide protection against oxidative neurodegeneration. In this investigation, the presence of MAO-B in rat C6 astrocyte cells was substantiated by dose-dependent inhibition of enzyme activity in the presence of chlorgyline-HCl and L-deprenyl. The present study evaluated various dietary-derived food constituents for evidence of inhibition on oxidative deamination of monoamines or peroxide radical trapping capacity. Results of this investigation indicate that compounds which inhibit C6 glial cell MAO enzyme activity or scavenge peroxide product include chlorogenic acid, (+)-catechin, taxifolin, (-)-epigallocatechin gallate (EGCG), fisetin, coenzyme Q0, curcumin, sesamol, morin, sesame oil, silymarin, green tea, ferulic acid, caffeic acid, and rutin hydrate. The results of this study indicate that dietary compounds can attenuate peroxide production in glial cells by either inhibiting the deamination of monoamines or acting as a free radical scavenger.
胶质细胞单胺氧化酶（MAO）活性被认为是与各种神经退行性疾病相关的氧化性神经元损伤的一个促成因素。MAO活性的减弱可能为对抗氧化性神经退行性变提供保护。在本研究中，通过在存在盐酸氯吉兰和L-司来吉兰的情况下酶活性的剂量依赖性抑制，证实了大鼠C6星形胶质细胞中MAO-B的存在。本研究评估了各种饮食来源的食物成分，以寻找对单胺氧化脱氨的抑制或过氧化物自由基捕获能力的证据。本研究结果表明，抑制C6胶质细胞MAO酶活性或清除过氧化物产物的化合物包括绿原酸、（+）-儿茶素、紫杉叶素、（-）-表没食子儿茶素没食子酸酯（EGCG）、非瑟酮、辅酶Q0、姜黄素、芝麻酚、桑色素、芝麻油、水飞蓟宾、绿茶、阿魏酸、咖啡酸和芦丁水合物。本研究结果表明，饮食化合物可通过抑制单胺脱氨或作为自由基清除剂来减弱胶质细胞中的过氧化物生成。
