苯妥英预处理后家兔苯妥英代谢增加。
Increased phenytoin metabolism in rabbits after phenytoin pretreatment.
作者信息
Wilensky A J, Lowden J A
出版信息
Res Commun Chem Pathol Pharmacol. 1976 Oct;15(2):365-8.
PMID:981792
Abstract
The serum half-life of phenytoin in rabbits after a single intravenous dose was significantly shortened by pretreating the rabbits with daily oral doses of phenytoin. This suggests that in vivo phenytoin induces its own metabolism.
摘要
单次静脉注射剂量后，家兔体内苯妥英的血清半衰期在每日口服苯妥英预处理后显著缩短。这表明体内苯妥英会诱导自身代谢。
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