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Profound symptomatic bradycardia associated with combined mibefradil and beta-blocker therapy.

作者信息

Rogers R, Prpic R

机构信息

Sir Charles Gairdner Hospital, Nedlands, WA.

出版信息

Med J Aust. 1998 Oct 19;169(8):425-7.

PMID:9830391
Abstract

We report two cases where the addition of mibefradil to long term beta-blocker therapy in managing hypertension produced profound symptomatic bradycardia requiring cardiac pacing. Reports of a number of interactions between mibefradil and other cardioactive drugs have now led to its withdrawal from the market worldwide.

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