Myhre K, Steen J B, Stray-Pedersen S
Acta Physiol Scand. 1976 Oct;98(2):200-8. doi: 10.1111/j.1748-1716.1976.tb00237.x.
Measurements of transcapillary exchange of high-molecular dextrans, K+ and THO in the rete mirabile of eel (Anguilla vulgaris L.) have been made under steady-state conditions while the transcapillary pressure was varied and pharmaca added to the perfusates. Raising the transcapillary input pressure increased the exchange of dextrans and K+ but lowered that of THO. Histamine and ouabain had no effect on the transcapillary exchange of the test molecules. The highest dose (100 mug/ml) of serotonin reversibly increased the capillary permeability of D-75 000, K+ and THO while the medium dose (50 mug/ml) only raised the transcapillary exchange of K+ and THO. The lowest dose (10 mug/ml) had no permeability effect. Our main conclusion is that serotonin reversibly increases the area of the intercellular pores by affecting the capillary wall directly.
在稳态条件下，当改变跨毛细血管压力并向灌注液中添加药物时，对欧洲鳗鲡（Anguilla vulgaris L.）奇网中的高分子右旋糖酐、K⁺和THO的跨毛细血管交换进行了测量。提高跨毛细血管输入压力会增加右旋糖酐和K⁺的交换，但会降低THO的交换。组胺和哇巴因对测试分子的跨毛细血管交换没有影响。最高剂量（100微克/毫升）的血清素可逆地增加了D - 75000、K⁺和THO的毛细血管通透性，而中等剂量（50微克/毫升）仅提高了K⁺和THO的跨毛细血管交换。最低剂量（10微克/毫升）没有通透性影响。我们的主要结论是，血清素通过直接影响毛细血管壁可逆地增加细胞间孔隙的面积。
