家族性卡波西肉瘤与骨佩吉特病。

Familial Kaposi's sarcoma and Paget's disease of bone.

作者信息

Hale L R, Kelly J W

机构信息

Dermatology Unit, Alfred Hospital, Prahran, Victoria, Australia.

出版信息

Australas J Dermatol. 1998 Nov;39(4):241-3. doi: 10.1111/j.1440-0960.1998.tb01481.x.

DOI:10.1111/j.1440-0960.1998.tb01481.x

PMID:9838721

Abstract

Familial Kaposi's sarcoma and familial Paget's disease of bone have not previously been reported to occur in the one patient or the one family. We report on an 82-year-old female of Lebanese descent who was recently diagnosed with Kaposi's sarcoma and Paget's disease. Of the patient's eight siblings, seven had Paget's disease and two of these also had Kaposi's sarcoma. Histocompatibility leucocyte antigen (HLA) class I and II typing of the patient showed: A2, A3; B35, Bx; Bw6; Cw4; DR beta 11101 (an HLA-DR5 subtype), DR beta 3 and DQ beta 10301. Previous reports have described possible associations of familial Kaposi's sarcoma with HLA-DR5 and Paget's disease with DR2. DR beta 11104, DP beta 104 and DQw1. Genetic factors and possible viral aetiologies for each condition are reviewed.

摘要

家族性卡波西肉瘤和家族性骨佩吉特病此前尚未有在同一患者或同一家族中发生的报道。我们报告了一位82岁的黎巴嫩裔女性，她最近被诊断患有卡波西肉瘤和佩吉特病。在该患者的8个兄弟姐妹中，7人患有佩吉特病，其中2人还患有卡波西肉瘤。对该患者进行的组织相容性白细胞抗原（HLA）Ⅰ类和Ⅱ类分型显示：A2、A3；B35、Bx；Bw6；Cw4；DRβ11101（一种HLA-DR5亚型）、DRβ3和DQβ10301。此前的报道描述了家族性卡波西肉瘤与HLA-DR5以及佩吉特病与DR2之间可能存在的关联。DRβ11104、DPβ104和DQw1。对每种疾病的遗传因素和可能的病毒病因进行了综述。