Hay J B, Andrade W N
Department of Immunology, Faculty of Medicine, University of Toronto, ON, Canada.
Can J Physiol Pharmacol. 1998 May;76(5):490-6. doi: 10.1139/cjpp-76-5-490.
Alterations in leukocyte concentrations in the blood are associated with exercise, stress, and other pathophysiological perturbations. The continuous migration and redistribution of cells of the recirculating lymphocyte pool between the blood and lymphatic systems can be influenced by a variety of physiological, immunological, and pathological processes. The phenotypic distribution of lymphocyte subsets is not the same in blood, afferent lymph, and efferent lymph, and cell-tracking experiments have shown that lymphocytes vary in their migratory properties. The most comprehensive physiological studies tracking these cells in vivo have been done in sheep. It has been shown that lymph-derived cells have different migratory capacities than blood-derived lymphocytes, that antigenic challenge of a single lymph node can first reduce the output of lymphocytes from the node and then markedly increase the recruitment from the blood and subsequently the output into efferent lymph. In most mammals, the blood pool of lymphocytes represents only about 1% of the total lymphocytes and only a small fraction of the recirculating lymphocyte pool. Therefore, testing the effects of exercise on lymphocyte recirculation by examining blood samples only requires considerable deduction and inference to interpret multicompartmental effects.
血液中白细胞浓度的改变与运动、压力及其他病理生理扰动有关。循环淋巴细胞池中细胞在血液和淋巴系统之间的持续迁移和再分布会受到多种生理、免疫和病理过程的影响。淋巴细胞亚群的表型分布在血液、输入淋巴和输出淋巴中并不相同，细胞追踪实验表明淋巴细胞的迁移特性存在差异。在绵羊身上进行了最全面的体内追踪这些细胞的生理研究。结果表明，淋巴来源的细胞与血液来源的淋巴细胞具有不同的迁移能力，单个淋巴结受到抗原刺激时，首先会减少该淋巴结淋巴细胞的输出，然后显著增加从血液中的募集，随后增加输出到输出淋巴中的数量。在大多数哺乳动物中，淋巴细胞的血液池仅占淋巴细胞总数的约1%，仅是循环淋巴细胞池的一小部分。因此，仅通过检测血液样本测试运动对淋巴细胞再循环的影响，需要进行大量的推导和推断才能解释多室效应。
