血管紧张素II对大鼠海马体中γ-氨基丁酸释放的体外作用。
In vitro effect of angiotensin II on GABA release in rat hippocampus.
作者信息
Hadjiivanova C H, Georgiev V
机构信息
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
出版信息
Neuropeptides. 1998 Oct;32(5):431-4. doi: 10.1016/s0143-4179(98)90067-1.
In rat hippocampal slices [3H]GABA release evoked by 25 mM KCI consisted of Ca2+-dependent and Ca2+-independent fractions. Angiotensin II (AngII) at a concentration of 1 microM inhibited K+-stimulated [3H]GABA release. The effect of AngII (20% inhibition) on [3H]GABA release was decreased by the addition of 0.01 mM nipecotic acid to the superfusion medium. AngII also decreased the Ca2+-independent carrier-mediated [3H]GABA release (25% inhibition at a concentration of 1 microM). Different mechanisms of the neuromodulatory action of AngII on GABA release are discussed.
在大鼠海马切片中，25 mM氯化钾诱发的[3H]GABA释放由钙依赖性和非钙依赖性部分组成。浓度为1 microM的血管紧张素II（AngII）抑制钾离子刺激的[3H]GABA释放。向灌流培养基中添加0.01 mM的尼克酸可降低AngII（20%抑制率）对[3H]GABA释放的作用。AngII还降低了非钙依赖性载体介导的[3H]GABA释放（浓度为1 microM时抑制率为25%）。文中讨论了AngII对GABA释放的神经调节作用的不同机制。
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