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体外冲击波碎石术后抗肾小球基底膜肾炎

Anti-glomerular basement membrane nephritis after extracorporeal shock wave lithotripsy.

作者信息

Iwamoto I, Yonekawa S, Takeda T, Sakaguchi M, Ohno T, Tanaka H, Hasegawa H, Imada A, Horiuchi A, Umekawa T, Kurita T

机构信息

Third Department of Internal Medicine, Kinki University School of Medicine, Osaka, Japan.

出版信息

Am J Nephrol. 1998;18(6):534-7. doi: 10.1159/000013401.

Abstract

Rapidly progressive glomerulonephritis was observed in a 37-year-old woman following the administration of extracorporeal shock wave lithotripsy (ESWL) for a single stone in her right kidney. The renal biopsy specimen showed diffuse cellular crescents in all glomeruli, with linear deposits of immunoglobulin G and complement component C3 along the glomerular basement membrane (GBM). Circulating anti-GBM antibodies were detected by enzyme-linked immunosorbent assay. Thus, the patient was diagnosed with anti-GBM nephritis. It is suggested that ESWL produced an alteration in the GBM leading to the production of anti-GBM antibodies.

摘要

一名37岁女性在接受体外冲击波碎石术(ESWL)治疗右肾单个结石后,出现了快速进展性肾小球肾炎。肾活检标本显示所有肾小球均有弥漫性细胞性新月体形成,免疫球蛋白G和补体成分C3沿肾小球基底膜(GBM)呈线性沉积。通过酶联免疫吸附测定法检测到循环抗GBM抗体。因此,该患者被诊断为抗GBM肾炎。提示ESWL导致GBM发生改变,从而产生抗GBM抗体。

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