[Physiological analysis of stress-induced changes in the suppressor activity of mouse T-lymphocytes].

Suppressor activity of the T-lymphocytes was studied by means of evaluating the alterations in humoral immune response in the system of adoptive transfer of splenocytes from immunised donors (PFC/106 splenocytes) in mice. Administration of glucocorticoids or stress prior to the immunisation decreased the suppressor activity of the T-lymphocytes and enhanced humoral immune response. In adrenalectomised mice, absence of glucocorticoid hormones in the blood did not prevent normal development of the suppressor functions of the T-lymphocytes. Administration of Interleukin-1 prior to the stress or hydrocortisone administration normalised the T-lymphocytes' functions.