Obtulowicz K, Cichocka-Jarosz E
Fac. of Medicine, Department of Industrial Allergology, Cracow, Poland.
Allerg Immunol (Paris). 1998 Oct;30(8):250-4.
In the group of 50 patients suffering from grass pollen allergy and successfully treated with SIT for three consecutive years, we observed in 5 persons after the end of this treatment the induction of allergy to new allergens (to weeds, mites or tree) manifested by the change of the symptoms season. The induction of the new kind of allergy was confirmed by revealing of the positive skin prick tests to new allergens and by an increase of the specific IgE serum level to them. Despite disappearance of the symptoms of the illness during grass pollen season in all 5 patients we noted the higher total IgE as well as specific to grasses IgE serum level, in comparison to the value at the start of SIT. In the paper the possible mechanisms of this phenomenon are discussed, which seems to be not connected with the natural development of allergy and which confirms once more that during SIT individual changes in humoral and cellular immunity of the patient take place, sometimes very difficult to be predicted. They may among others switch clinical profile of allergy, what indicates that patient during SIT should be under the careful immunological supervision.
在50例患有草花粉过敏且连续三年成功接受特异性免疫治疗（SIT）的患者组中，我们观察到在该治疗结束后，有5人出现了对新过敏原（杂草、螨虫或树木）的过敏反应，表现为症状季节的变化。通过对新过敏原进行皮肤点刺试验呈阳性以及血清中针对这些过敏原的特异性IgE水平升高，证实了新的过敏类型的诱发。尽管在所有5例患者的草花粉季节期间疾病症状消失，但与SIT开始时的值相比，我们注意到总IgE以及针对草的特异性IgE血清水平更高。本文讨论了这种现象的可能机制，这似乎与过敏的自然发展无关，并且再次证实了在SIT期间患者的体液和细胞免疫会发生个体变化，有时很难预测。这些变化尤其可能改变过敏的临床特征，这表明患者在SIT期间应接受仔细的免疫监测。
