Fry C H, Wu C, Sui G P
Institute of Urology and Nephrology, University College, London, UK.
Int Urogynecol J Pelvic Floor Dysfunct. 1998;9(5):291-8. doi: 10.1007/BF01901509.
The electrophysiological properties of detrusor smooth muscle are described, in particular with regard to their influence on the contractile properties of the tissue. The Ca2+ and K+ channel activities are most important in generating action potentials, but the role of several other ionic currents is described, including Cl-, Ca2+-activated, stretch-activated and ligand-gated channels. The variable appearance and functions of different ionic currents in disease states is discussed, as well as the question of whether electrical activity can transmit between adjacent smooth muscle cells. In addition, the precise role that electrophysiological phenomena play in the regulation of the contractile state of the smooth muscle cells, as well as the generation of bladder electromyograms, is discussed.
本文描述了逼尿肌平滑肌的电生理特性，特别是其对组织收缩特性的影响。Ca2+和K+通道活性在产生动作电位方面最为重要，但也描述了其他几种离子电流的作用，包括Cl-、Ca2+激活、牵张激活和配体门控通道。讨论了疾病状态下不同离子电流的可变表现和功能，以及电活动是否能在相邻平滑肌细胞之间传递的问题。此外，还讨论了电生理现象在调节平滑肌细胞收缩状态以及膀胱肌电图产生中所起的精确作用。
