Da Costa A R, Monzillo P H, Sanvito W L
Disciplina de Neurologia, Faculdade de Ciências Médicas, Santa Casa de São Paulo, Brasil.
Arq Neuropsiquiatr. 1998 Sep;56(3B):565-8. doi: 10.1590/s0004-282x1998000400008.
Therapeutic measures, with intravenous chlorpromazine, taken during acute headache are evaluated in fourteen patients at the emergency room in Santa Casa de São Paulo. Four patients had the diagnosis of migraine with aura and five patients migraine without aura. Four patients had diagnosis of chronic daily headache with intermittent and superimposed migrainous events. Finally one patient had the diagnosis of chronic paroxysmal hemicrania. All patients were diagnosed according to International Headache Society criteria. The intravenous chlorpromazine dose used was 0.7 mg/Kg diluted in 5% glucose solution and the dose never exceeded 50 mg. The time of drug administration was never less than 60 minutes. The results were considered excellent in all cases. Some patients presented side effects, particularly orthostatic hypotension, always moderate and transitory. This study has clearly demonstrated that intravenous chlorpromazine (0.7 mg/Kg) was highly effective in terminating episodes of primary headache.
在圣保罗圣卡塔琳娜医院急诊室,对14例急性头痛患者采取静脉注射氯丙嗪的治疗措施进行了评估。4例患者诊断为伴有先兆的偏头痛,5例患者诊断为无先兆偏头痛。4例患者诊断为慢性每日头痛伴间歇性和叠加性偏头痛发作。最后1例患者诊断为慢性阵发性半侧头痛。所有患者均根据国际头痛协会标准进行诊断。静脉注射氯丙嗪的剂量为0.7mg/kg,用5%葡萄糖溶液稀释,剂量从未超过50mg。给药时间从不小于60分钟。所有病例结果均被认为极佳。一些患者出现了副作用,尤其是体位性低血压,均为中度且短暂性。本研究清楚地表明,静脉注射氯丙嗪(0.7mg/kg)在终止原发性头痛发作方面非常有效。