Medvedev O S, Kunduzova O R, Murashev A N, Medvedeva N A
Faculty of Basic Medicine, Department of Pharmacology, Moscow State University, Russian Federation.
J Auton Nerv Syst. 1998 Oct 15;72(2-3):170-6. doi: 10.1016/s0165-1838(98)00102-7.
In the present study we investigated the chronopharmacological dependence of dose-dependent hypotensive and cardiochronotropic effects of the imidazoline-like drugs (clonidine, rilmenidine and moxonidine) in stroke-prone spontaneously hypertensive rats (SHR-SP), using radio-telemetric system (Data Sciences, USA). The 24-h blood pressure, heart rate and locomotor activity profiles showed peak values during the rats' active phase during the night period. The degree of hypotensive and bradycardic effects of all drugs were most evident at this time and occurred in the absence of a change in locomotor activity. These studies show that clonidine, rilmenidine and moxonidine decrease blood pressure and heart rate in a time-dependent manner in SHR-SP. It was demonstrated that the degree and duration of hypotensive action of imidazoline-like drugs vary with the time of drug administration.
在本研究中，我们使用美国Data Sciences公司的无线电遥测系统，研究了咪唑啉类药物（可乐定、利美尼定和莫索尼定）对易卒中型自发性高血压大鼠（SHR-SP）剂量依赖性降压和心脏变时性作用的时辰药理学依赖性。24小时血压、心率和运动活动曲线显示，大鼠夜间活跃期出现峰值。所有药物的降压和心动过缓作用程度此时最为明显，且运动活动无变化。这些研究表明，可乐定、利美尼定和莫索尼定在SHR-SP中以时间依赖性方式降低血压和心率。结果表明，咪唑啉类药物降压作用的程度和持续时间随给药时间而异。
