Kato Y, Tani T, Sotomaru Y, Kurokawa K, Kato J, Doguchi H, Yasue H, Tsunoda Y
Laboratory of Animal Reproduction, College of Agriculture and Research Institute for Animal Developmental Biotechnology, Kinki University, 3327-204, Nakamachi, Nara, 631-8505, Japan.
Science. 1998 Dec 11;282(5396):2095-8. doi: 10.1126/science.282.5396.2095.
Eight calves were derived from differentiated cells of a single adult cow, five from cumulus cells and three from oviductal cells out of 10 embryos transferred to surrogate cows (80 percent success). All calves were visibly normal, but four died at or soon after birth from environmental causes, and postmortem analysis revealed no abnormality. These results show that bovine cumulus and oviductal epithelial cells of the adult have the genetic content to direct the development of newborn calves.
八头小牛源自一头成年母牛的分化细胞，其中五头来自卵丘细胞，三头来自输卵管细胞，共向代孕母牛移植了10个胚胎（成功率为80%）。所有小牛外观均正常，但有四头在出生时或出生后不久因环境原因死亡，尸检分析未发现异常。这些结果表明，成年牛的卵丘和输卵管上皮细胞具有指导新生小牛发育的遗传物质。
