妊娠合并HELLP综合征后的肝功能

Liver function following pregnancy complicated by the HELLP syndrome.

作者信息

Knapen M F, van Altena A M, Peters W H, Merkus H M, Jansen J B, Steegers E A

机构信息

Department of Obstetrics and Gynaecology, University Hospital St Radboud, Nijmegen, The Netherlands.

出版信息

Br J Obstet Gynaecol. 1998 Nov;105(11):1208-10. doi: 10.1111/j.1471-0528.1998.tb09977.x.

DOI:10.1111/j.1471-0528.1998.tb09977.x

PMID:9853772

Abstract

Serum levels of aminotransferases, lactate dehydrogenase, gammaglutamyl transferase, alkaline phosphatase, albumin and conjugated bilirubin, measured in 54 women at a median of 31 months (range 3-101) after pregnancies complicated by the HELLP syndrome, were not elevated. Total bilirubin levels, however, were elevated in 20% of these women; this represents a significant difference from the prevalence in 151 women with a previous normal pregnancy (chi2 = 12.23, P < 0.001), or in the normal female population (chi2 = 22.34, P < 0.00001). This raises the possibility that a dysfunction of the bilirubin-conjugating mechanism represents a risk factor for the development of the HELLP syndrome.

摘要

在54名妊娠合并HELLP综合征的女性中，于妊娠后中位时间31个月（范围3 - 101个月）测定的血清转氨酶、乳酸脱氢酶、γ-谷氨酰转移酶、碱性磷酸酶、白蛋白和结合胆红素水平均未升高。然而，这些女性中有20%的总胆红素水平升高；这与151名既往妊娠正常的女性（χ² = 12.23，P < 0.001）或正常女性人群（χ² = 22.34，P < 0.00001）的患病率存在显著差异。这增加了胆红素结合机制功能障碍是HELLP综合征发生的一个危险因素的可能性。