高脂胆固醇饮食喂养大鼠的抗坏血酸代谢

Ascorbic acid metabolism in rats fed high fat cholesterol diet.

作者信息

Nambisan B, Kurup P A

出版信息

Atherosclerosis. 1976 Oct;25(1):63-9. doi: 10.1016/0021-9150(76)90048-4.

Abstract

The synthesis and catabolism of ascorbic acid has been studied in rats fed an atherogenic diet as also has the relation between the concentration of ascorbic acid and concentration of lipids in the tissues. The concentration of ascorbic acid was found to decrease in the serum, liver, spleen and adrenals, but not in the kidney, in the animals fed an atherogenic diet when compared with those fed normal diet. An inverse relationship was found between the concentration of ascorbic acid in the tissue and the concentration of lipids. The synthesis of ascorbic acid from D-glucuronalactone did not significantly differ in the liver and kidney, but decreased in the spleen in the animals fed the atherogenic diet. On the other hand, the catabolism of ascorbic acid significantly increased in the liver and spleen.

摘要

已经对喂食致动脉粥样化饮食的大鼠体内抗坏血酸的合成与分解代谢进行了研究，同时也研究了抗坏血酸浓度与组织中脂质浓度之间的关系。与喂食正常饮食的动物相比，发现喂食致动脉粥样化饮食的动物血清、肝脏、脾脏和肾上腺中的抗坏血酸浓度降低，但肾脏中的抗坏血酸浓度未降低。在组织中抗坏血酸浓度与脂质浓度之间发现了负相关关系。从D - 葡糖醛酸内酯合成抗坏血酸在肝脏和肾脏中没有显著差异，但在喂食致动脉粥样化饮食的动物的脾脏中有所下降。另一方面，肝脏和脾脏中抗坏血酸的分解代谢显著增加。