Fleidervish I A, Binshtok A M, Gutnick M J
Zlotowski Center for Neuroscience and Department of Physiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beersheva, Israel.
Neuron. 1998 Nov;21(5):1055-65. doi: 10.1016/s0896-6273(00)80623-6.
In sensory areas of neocortex, thalamocortical afferents project primarily onto the spiny stellate neurons of Layer 4. Anatomical evidence indicates that these cells receive most of their excitatory input from other cortical neurons, including other spiny stellate cells. Although this local network must play an important role in sensory processing, little is known about the properties of the neurons and synapses involved. We have produced a slice preparation of mouse barrel cortex that isolates Layer 4. We report that excitatory interaction between spiny stellate neurons is largely via N-methyl-D-aspartate receptors (NMDARs) and that a given neuron contains more than one type of NMDAR, as distinguished by voltage dependence. Thus, spiny stellate cells act as effective integrators of powerful and persistent NMDAR-mediated recurrent excitation.
在新皮质的感觉区域，丘脑皮质传入纤维主要投射到第4层的棘状星型神经元上。解剖学证据表明，这些细胞的大部分兴奋性输入来自其他皮质神经元，包括其他棘状星型细胞。尽管这个局部网络在感觉处理中一定起着重要作用，但对于所涉及的神经元和突触的特性却知之甚少。我们制备了分离出第4层的小鼠桶状皮质脑片标本。我们报告称，棘状星型神经元之间的兴奋性相互作用主要通过N-甲基-D-天冬氨酸受体（NMDARs）进行，并且一个给定的神经元包含不止一种类型的NMDAR，可通过电压依赖性来区分。因此，棘状星型细胞充当了强大且持久的NMDAR介导的反复兴奋的有效整合器。
