儿童肝移植后巨细胞病毒感染的诊断与监测
Diagnosis and monitoring of cytomegalovirus infection after liver transplantation in children.
作者信息
Kaliciński P, Kamiński A, Prokurat A, Drewniak T, Chrupek M, Ochalska B, Dzierzanowska D, Szymczak M, Ismail H, Pawłowska J, Kamiński W
机构信息
Department of General Surgery, Child's Health Center Memorial Hospital, Warsaw, Poland.
出版信息
Ann Transplant. 1996;1(2):13-4.
Cytomegalovirus infection (CMV) complicated the posttransplant course in 9 of 24 children after liver transplantation. We found specific antibodies (IgG and IgM) to be of very low value in diagnosis and monitoring of CMV infection after liver transplantation. Detection of CMV-DNA by PCR method in the blood or urine was very useful for diagnosis, but less for monitoring of the course of disease and its treatment. Measurements of early immediate CMV antigen (IEA), in peripheral blood leucocytes allowed for very early diagnosis of CMV infection and correlated well with the course of disease and response to treatment of the patient.
24例儿童肝移植后，有9例出现巨细胞病毒感染（CMV）并使移植后的病程复杂化。我们发现特异性抗体（IgG和IgM）在肝移植后CMV感染的诊断和监测中价值极低。通过PCR方法检测血液或尿液中的CMV-DNA对诊断非常有用，但对疾病病程及其治疗的监测作用较小。检测外周血白细胞中的早期即刻CMV抗原（IEA）可实现CMV感染的极早期诊断，且与患者的疾病病程及治疗反应相关性良好。
Zotero 插件