Sár C P, Hideg E, Vass I, Hideg K
Institute of Organic and Medicinal Chemistry, University of Pécs, Hungary.
Bioorg Med Chem Lett. 1998 Feb 17;8(4):379-84. doi: 10.1016/s0960-894x(98)00033-x.
alpha-Aryl N-adamant-1-yl nitrones were synthesized and evaluated with respect to the stability of the hydroxyl radical adduct. The polarity and water solubility of nitrones were altered with changing the alpha-aryl groups. Introduction of adamantane ring instead of tert-butyl group resulted in a reasonable good stability of hydroxyl radical adduct for biological measurements.
合成了α-芳基-N-金刚烷-1-基硝酮，并对其羟基自由基加合物的稳定性进行了评估。随着α-芳基的变化，硝酮的极性和水溶性也发生了改变。用金刚烷环取代叔丁基，使得羟基自由基加合物在生物测量中具有相当好的稳定性。
