新型两亲性茶多酚衍生物的合成及其抗氧化活性
Synthesis and antioxidant activity of novel amphipathic derivatives of tea polyphenol.
作者信息
Tanaka T, Kusano R, Kouno I
机构信息
School of Pharmaceutical Sciences, Nagasaki University, Japan.
出版信息
Bioorg Med Chem Lett. 1998 Jul 21;8(14):1801-6. doi: 10.1016/s0960-894x(98)00311-4.
Hydrophobic derivatives of a tea polyphenol have been synthesized. 6, 8-Bis(octylthiomethyl)-epigallocatechin 3-O-gallate, 6, 8-bis(octylthiomethyl)-4 beta-(2-hydroxyethylthio)epigallocatechin 3-O-gallate and epigallocatechin 3-O-[4-O-(N-octadecylcarbamoyl)gallate] showed strong inhibition activity against lipid peroxidation of liposome caused by both lipid-soluble and water-soluble radical generators.
一种茶多酚的疏水衍生物已被合成。6,8 - 双（辛硫基甲基）- 表没食子儿茶素3 - O - 没食子酸酯、6,8 - 双（辛硫基甲基）- 4β - （2 - 羟乙基硫基）表没食子儿茶素3 - O - 没食子酸酯和表没食子儿茶素3 - O - [4 - O - （N - 十八烷基氨基甲酰基）没食子酸酯]对由脂溶性和水溶性自由基引发剂引起的脂质体脂质过氧化表现出强烈的抑制活性。
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