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[低剂量和低剂量率下人类辐射致癌的特征]

[Features of radiation carcinogenesis in man at low doses and low dose rates].

作者信息

Keirim-Markus I B

机构信息

State Research Centre of Russia-Institute of Biophysics, Moscow.

出版信息

Radiats Biol Radioecol. 1998 Sep-Oct;38(5):672-83.

PMID:9876491
Abstract

The accepted linear no-threshold (LNT) dose response for stochastic effects is not valid even for the cellular level. Published data on the human radiation carcinogenesis demonstrate now the radiation hormesis or the absence of effects or its reduction in the whole low dose interval when a dose rate is decreased. This is demonstrated for leukemia and for lung, breast, thyroid, bone, skin and liver solid cancers, for such organs, which are responsible in the more, than 1/2 of cancer detriment postulated by the ICRP. It is possible valid for the whole of solid cancers and for nontumorogenic death.

摘要

即使在细胞水平上,公认的随机效应线性无阈(LNT)剂量反应也是无效的。关于人类辐射致癌作用的已发表数据表明,当剂量率降低时,在整个低剂量区间内存在辐射兴奋效应,即无效应或效应减弱。这在白血病以及肺癌、乳腺癌、甲状腺癌、骨癌、皮肤癌和肝癌等实体癌中得到了证实,这些器官所导致的癌症危害超过了国际放射防护委员会(ICRP)假设的癌症危害的一半以上。对于所有实体癌和非致瘤性死亡而言,这可能是有效的。

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