Tsunoda Y, Shibusawa M, Tsunoda A, Gomi A, Yatsuzuka M, Okamatsu T
Department of Surgery, School of Medicine, Showa University, Tokyo, Japan.
Anticancer Res. 1998 Nov-Dec;18(6A):4339-42.
A six month-old girl presented with an abdominal mass, and high serum level of alpha-fetoprotein. She was diagnosed as having a well-differentiated hepatoblastoma by open biopsy. The biopsy specimen was transplanted on a nude mouse, and a xenograft was successfully established. Because the xenograft maintained the characteristics of the original tumor, the effect of hepatocyte growth factor (HGF) on hepatoblastoma xenograft was investigated. Recently HGF was reported to be involved in growth, invasion, and metastasis of tumor cells. Contrary to our expectations, the treatment of hepatoblastoma xenograft with recombinant 20 ng/ml HGF produced a marked inhibition of cell growth and a suppression of producing alpha-fetoprotein.
一名6个月大的女孩出现腹部肿块，血清甲胎蛋白水平升高。经开放活检，她被诊断为高分化肝母细胞瘤。将活检标本移植到裸鼠身上，成功建立了异种移植瘤。由于异种移植瘤保持了原发肿瘤的特征，因此研究了肝细胞生长因子（HGF）对肝母细胞瘤异种移植瘤的作用。最近有报道称HGF与肿瘤细胞的生长、侵袭和转移有关。与我们的预期相反，用重组20 ng/ml HGF治疗肝母细胞瘤异种移植瘤可显著抑制细胞生长并抑制甲胎蛋白的产生。
