尿液中3,4-二羟基苯甲酰芽子碱的气相色谱/质谱分析。可卡因使用的法医学意义。
GC/MS analysis of m-hydroxybenzoylecgonine in urine. Forensic implication in cocaine use.
作者信息
elSohly M A, Kopycki W J, Feng S, Murphy T P, Lukey B J
机构信息
ElSohly Laboratories, Incorporated, Oxford, Mississippi, USA.
出版信息
Clin Lab Med. 1998 Dec;18(4):699-704, ix.
m-Hydroxybenzoylecgonine (m-OH-BE) and d3-m- hydroxybenzoylecgonine (d3-m-OH-BE) have been synthesized, and a GC/MS procedure with d3-m-OH-BE as internal standard has been developed. Among 24 human urine specimens that were positive for BE, all of them have shown detectable levels of m-OH-BE with 75% of the specimens exceeding the LoQ (5 ng/mL), compared with only 50% of the specimens containing detectable levels of EME. The presence of m-OH-BE in urine suggested that this metabolite may serve as a valuable marker of cocaine use in addition to BE and EME.
间羟基苯甲酰芽子碱（m-OH-BE）和氘代间羟基苯甲酰芽子碱（d3-m-OH-BE）已被合成，并且已开发出一种以d3-m-OH-BE作为内标的气相色谱/质谱方法。在24份苯甲酰芽子碱呈阳性的人体尿液样本中，所有样本均显示出可检测到的间羟基苯甲酰芽子碱水平，其中75%的样本超过定量限（5 ng/mL），相比之下，只有50%的样本含有可检测水平的去甲麻黄碱。尿液中间羟基苯甲酰芽子碱的存在表明，除了苯甲酰芽子碱和去甲麻黄碱外，这种代谢物可能是可卡因使用的一个有价值的标志物。
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