Nemerson Y
Thromb Haemost. 1976 Feb 29;35(1):96-100.
The tissue factor pathway is initiated by factor VII in the presence of tissue factor. The first proteolytic reaction involves cleavage of factor X by factor VII. Activated factor X, the product of this reaction, can activate factor VII by cleavage of a specific bond. The apparent coagulant activity of factor VII then rises about 60-fold. Activated factor X can also inactivate factor VII by catalyzing the cleavage of a second bond which results in a three chain molecule. Fragments of Hageman factor and perhaps kallikrein can also activate factor VII. Hageman factor, however, does not catalyze the inactivating cleavage of factor VII at a significant rate. Recent data showing that the tissue factor pathway can activate the intrinsic system are discussed. We have shown that activated factor X, which can be generated by the tissue factor pathway, can feed back and activate factor IX in a calcium and phospholipid requiring reaction.
组织因子途径由组织因子存在时的因子 VII 启动。第一个蛋白水解反应涉及因子 VII 对因子 X 的裂解。该反应的产物活化因子 X 可通过裂解特定键来激活因子 VII。然后因子 VII 的表观促凝活性升高约 60 倍。活化因子 X 还可通过催化第二条键的裂解使因子 VII 失活，这会产生一个三链分子。哈格曼因子片段以及可能的激肽释放酶也可激活因子 VII。然而，哈格曼因子不会以显著速率催化因子 VII 的失活裂解。本文讨论了近期表明组织因子途径可激活内源性系统的数据。我们已经表明，可由组织因子途径产生的活化因子 X 能够反馈并在需要钙和磷脂的反应中激活因子 IX。
