Stanley N, Fairweather D B, Hindmarch I
Human Psychopharmacology Research Unit, University of Surrey, Guildford, UK.
Neuropsychobiology. 1999;39(1):44-8. doi: 10.1159/000026559.
Psychomotor retardation is a recognised symptom of depressive illness, and improvement in psychomotor function is associated with the amelioration of the severity of depressive symptoms. Actigraphy permits behavioural activity to be continuously assessed, allowing changes in psychomotor activity to be monitored over time. A randomised, parallel-group, double-blind study was conducted in 14 general practice patients with a diagnosis of major depression. This pilot study was designed to investigate the utility of actigraphy in this patient population and to investigate possible differences between fluoxetine and dothiepin in their effects on 24-hour behavioural activity monitored for the first 10 days of treatment. Patients taking dothiepin (75 mg rising to 150 mg in the second week, nocte) were found to be significantly (p < 0.05) less active over the course of the day compared to those treated with fluoxetine (20 mg, mane). This lower level of behavioural activity in the dothiepin group was particularly noticeable in the early morning (06:00-08:00 h).
精神运动迟缓是抑郁症公认的症状，精神运动功能的改善与抑郁症状严重程度的减轻相关。活动记录仪可对行为活动进行持续评估，从而能够监测精神运动活动随时间的变化。对14名诊断为重度抑郁症的全科门诊患者进行了一项随机、平行组、双盲研究。这项初步研究旨在调查活动记录仪在该患者群体中的效用，并研究氟西汀和多塞平在治疗前10天对24小时行为活动影响方面可能存在的差异。结果发现，与服用氟西汀（20毫克，晨服）的患者相比，服用多塞平（75毫克，第二周增至150毫克，睡前服用）的患者在一天中的活动明显较少（p < 0.05）。多塞平组较低水平的行为活动在清晨（06:00 - 08:00）尤为明显。
