Lim C L, Gordon E, Harris A, Bahramali H, Li W M, Manor B, Rennie C
Department of Neurology, University of Sydney, Australia.
Biol Psychiatry. 1999 Jan 1;45(1):127-35. doi: 10.1016/s0006-3223(98)00056-0.
Electrodermal activity in response to short interstimulus interval (ISI) stimulation allows aspects of information processing to be examined, but such paradigms cause skin conductance responses (SCRs) to overlap. A signal decomposition method was developed and employed to score the overlapped SCRs. This is the first application of the method to the study of schizophrenia.
Electrodermal activity of 30 medicated patients with schizophrenia and 50 normal controls was obtained using a conventional auditory oddball paradigm with an ISI of 1.3 sec. Tonic skin conductance level (SCL), phasic SCRs, SCR temporal dynamics, and a range of SCR variables in response to target tones were examined.
The schizophrenic group showed reduced response rate, proportion of responders, SCR amplitude, rise time, peak latency, and steady-state response amplitude, over the trial compared with controls. There were no between-group differences in SCL or SCR onset time.
The combined use of a conventional short ISI paradigm and the new SCR scoring method demonstrated new facets of electrodermal hyporeactivity in medicated patients with schizophrenia. The hyporeactivity could not be attributed to changes in tonic arousal or dysfunctions in peripheral sympathetic nerve conductance.
对短刺激间隔（ISI）刺激的皮肤电活动可用于研究信息处理的各个方面，但此类范式会导致皮肤电导反应（SCR）重叠。为此开发并采用了一种信号分解方法来对重叠的SCR进行评分。这是该方法首次应用于精神分裂症研究。
使用传统听觉Oddball范式，刺激间隔为1.3秒，获取30例接受药物治疗的精神分裂症患者和50例正常对照者的皮肤电活动。检测静息皮肤电导水平（SCL）、相位性SCR、SCR的时间动态变化以及对目标音调的一系列SCR变量。
与对照组相比，精神分裂症组在整个试验过程中反应率、反应者比例、SCR幅度、上升时间、峰值潜伏期和稳态反应幅度均降低。两组在SCL或SCR起始时间上无差异。
传统短ISI范式与新的SCR评分方法联合使用，揭示了接受药物治疗的精神分裂症患者皮肤电反应低下的新特征。这种反应低下不能归因于静息觉醒的变化或外周交感神经传导功能障碍。
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