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Cloning of caf1+, caf2+ and caf4+ from Schizosaccharomyces pombe: their involvement in multidrug resistance, UV and pH sensitivity.

作者信息

Benko Z, Sipiczki M, Carr A M

机构信息

Trafford Centre, University of Sussex, Falmer, Brighton, UK.

出版信息

Mol Gen Genet. 1998 Dec;260(5):434-43. doi: 10.1007/s004380050914.

DOI:10.1007/s004380050914
PMID:9894913
Abstract

We previously identified four nuclear genes (caf1+ to caf4+) in Schizosaccharomyces pombe, mutations in which can confer caffeine resistance. Here we report the cloning and sequencing of caf1+, caf2+ and caf4+. All three genes are allelic to genes (hba1+, crm1+ and trr1+, respectively) involved in multidrug resistance mechanisms or in stress response systems. In agreement with this the caffeine-resistant mutants caf1(hba1)-21, caf2(crm1)-3 and caf4(trr1)-83 are also resistant to brefeldin. Disruption of caf1(hba1)+ and caf4(trr1)+ makes cells sensitive to high pH. The overlapping ranges of pleiotropic effects and the genetic interaction detected between caf1(hba1)+ and caf2(crm1)+ suggest that the three genes function in interlinked systems.

摘要

相似文献

1
Cloning of caf1+, caf2+ and caf4+ from Schizosaccharomyces pombe: their involvement in multidrug resistance, UV and pH sensitivity.
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bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily.bfr1+是粟酒裂殖酵母的一个赋予布雷菲德菌素A抗性的新基因，在结构上与ATP结合盒超家族相关。
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引用本文的文献

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The transcription factors Pap1 and Prr1 collaborate to activate antioxidant, but not drug tolerance, genes in response to H2O2.转录因子 Pap1 和 Prr1 协同作用，以响应 H2O2 激活抗氧化剂，但不激活耐药物基因。
Nucleic Acids Res. 2012 Jun;40(11):4816-24. doi: 10.1093/nar/gks141. Epub 2012 Feb 16.
2
Genome-wide screen of genes required for caffeine tolerance in fission yeast.裂殖酵母咖啡因耐受相关基因的全基因组筛选。
PLoS One. 2009 Aug 12;4(8):e6619. doi: 10.1371/journal.pone.0006619.
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The pleiotropic cell separation mutation spl1-1 is a nucleotide substitution in the internal promoter of the proline tRNACGG gene of Schizosaccharomyces pombe.
多效性细胞分离突变体spl1-1是粟酒裂殖酵母脯氨酸tRNACGG基因内部启动子中的一个核苷酸替换。
Curr Genet. 2009 Oct;55(5):511-20. doi: 10.1007/s00294-009-0262-x. Epub 2009 Jul 28.
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Role for RACK1 orthologue Cpc2 in the modulation of stress response in fission yeast.RACK1同源物Cpc2在裂殖酵母应激反应调节中的作用。
Mol Biol Cell. 2009 Sep;20(18):3996-4009. doi: 10.1091/mbc.e09-05-0388. Epub 2009 Jul 22.
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The transcription factor Pap1/Caf3 plays a central role in the determination of caffeine resistance in Schizosaccharomyces pombe.转录因子Pap1/Caf3在粟酒裂殖酵母咖啡因抗性的决定中起核心作用。
Mol Genet Genomics. 2004 Mar;271(2):161-70. doi: 10.1007/s00438-003-0967-3. Epub 2004 Feb 3.