1α,25-二羟基-2β-(3-羟基丙氧基)维生素D3（ED-71）相关类似物的合成及其对去卵巢大鼠骨矿物质流失的预防作用
Syntheses and preventive effects of analogues related to 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71) on bone mineral loss in ovariectomized rats.
作者信息
Ono Y, Kawase A, Watanabe H, Shiraishi A, Takeda S, Higuchi Y, Sato K, Yamauchi T, Mikami T, Kato M, Tsugawa N, Okano T, Kubodera N
机构信息
Chugai Pharmaceutical Co., Ltd, Tokyo, Japan.
出版信息
Bioorg Med Chem. 1998 Dec;6(12):2517-23. doi: 10.1016/s0968-0896(98)80025-4.
Analogues related to 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effects of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity.
与1α,25 - 二羟基 - 2β - (3 - 羟基丙氧基)维生素D3（ED - 71）（2）、26,27 - 二甲基ED - 71（3）和26,27 - 二乙基ED - 71（4）相关的类似物由石胆酸（5）合成。在研究这些类似物和ED - 71（2）对去卵巢大鼠骨矿物质流失的预防作用时，26,27 - 二甲基ED - 71（3）显示出最强的活性。
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