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[通过离子交换法从动物组织中分离肝素和硫酸软骨素]

[Isolation of heparin and chondroitin sulfate from animal tissue by an ion exchange method].

作者信息

Ivankin A N, Nekliudov A D

机构信息

Institute of Meat Industry, Moscow, Russia.

出版信息

Prikl Biokhim Mikrobiol. 1998 Nov-Dec;34(6):692-7.

PMID:9929895
Abstract

Isolation of mucopolysaccharides (heparin and chondroitin sulfate), from animal tissue by ion exchange was studied. The yields of heparin and chondroitin sulfate of up to 20,000-150,000 units/kg and 14 g/kg, respectively, can be obtained depending of the type of the raw material used and the sorbent, which absorbs heparin and chondroitin sulfate from aqueous solutions in amounts of 100-250 mg per g sorbent. Ion-exchange sorption of mucopolysaccharides on synthetic sorbents permits extracting fractions of these compounds with the maximum biological activity.

摘要

研究了通过离子交换从动物组织中分离粘多糖(肝素和硫酸软骨素)的方法。根据所用原料的类型和吸附剂的不同,肝素和硫酸软骨素的产量分别可达20,000 - 150,000单位/千克和14克/千克,该吸附剂从水溶液中吸收肝素和硫酸软骨素的量为每克吸附剂100 - 250毫克。粘多糖在合成吸附剂上的离子交换吸附能够提取出具有最大生物活性的这些化合物馏分。

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