Meyer W J, Diller E C, Bartter F C, Halberg F
J Clin Endocrinol Metab. 1976 Nov;43(5):1122-7. doi: 10.1210/jcem-43-5-1122.
The circadian periodicity of adrenal function in patients with congenital virilizing adrenal hyperplasia (CAH) was examined by measuring the urinary 17-ketosteroids, 17-hydroxycorticosteroids, sodium, and potassium. Patients with the salt-losing and the non-salt-losing types were studied with and without treatment. Cosine curves were fitted to the data by the least-squares method to determine the mesors, amplitudes, and acrophases of the variable for each patient. The data reveal distinct circadian rhythms for all variables measured whether or not the patient was receiving treatment. The acrophases for 17-ketosteroids and 17-hydroxycorticosteroids were between 1500 and 1800 h. These acrophases are about 6 h later than those for normal subjects. The treatment on a fixed daytime schedule for many years may have shifted the natural rhythm.
通过测量尿17 - 酮类固醇、17 - 羟皮质类固醇、钠和钾，研究了先天性肾上腺皮质增生症（CAH）患者肾上腺功能的昼夜节律。对失盐型和非失盐型患者在治疗和未治疗的情况下进行了研究。采用最小二乘法将余弦曲线拟合到数据中，以确定每位患者各变量的均数、振幅和峰相位。数据显示，无论患者是否接受治疗，所有测量变量均有明显的昼夜节律。17 - 酮类固醇和17 - 羟皮质类固醇的峰相位在15:00至18:00之间。这些峰相位比正常受试者的峰相位晚约6小时。多年固定白天时间表的治疗可能改变了自然节律。
