Nussberger J, Vetter W, Furrer J, Beckerhoff R, Würsten D, Schmied U, Siegenthaler W
Schweiz Med Wochenschr. 1976 Jun 12;106(24):831-4.
20 essential hypertension patients with diastolic blood pressure of 100-140 mm Hg were treated with increasing doses (15-45 mg/day by mouth) of pindolol for 14 weeks after an initial placebo period of 5 weeks. Systolic and diastolic blood pressure decreased significantly with as little as 15 mg of pindolol (p less than 0.001). No further changes in systolic and diastolic blood pressure were observed when the doses of pindolol were increased. Plasma renin activity (PRA) determined by radioimmunoassay did not change under increasing doses of pindolol. The blood pressure changes did not correlate with initial PRA or with individual changes in PRA under increasing doses with individual changes in PRA under increasing doses of pindolol. These results do not afford evidence for a renin-dependent hypotensive effect of pindolol.
20例舒张压为100 - 140mmHg的原发性高血压患者，在经过5周的初始安慰剂期后，接受了逐渐增加剂量（口服15 - 45mg/天）的吲哚洛尔治疗，为期14周。仅15mg的吲哚洛尔就能使收缩压和舒张压显著下降（p<0.001）。当吲哚洛尔剂量增加时，未观察到收缩压和舒张压有进一步变化。通过放射免疫测定法测定的血浆肾素活性（PRA）在吲哚洛尔剂量增加时未发生改变。血压变化与初始PRA或吲哚洛尔剂量增加时PRA的个体变化无关。这些结果并未提供证据表明吲哚洛尔具有肾素依赖性降压作用。
